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OBJECTIVES

Objectives

After studying this chapter, you should be able to:

  • Describe the components, development, and derivatives of the pharyngeal apparatus.

  • Describe the formation of the tongue from the lingual swellings and relate the tongue's innervation to its developmental origins.

  • Trace the embryonic descent of the thyroid gland.

  • Describe the formation of the face and palate by the fusion of facial prominences.

PHARYNGEAL APPARATUS

  • During weeks 4 and 5, a series of ridges develops bilaterally in the region of the primitive pharynx, constituting the pharyngeal (branchial) apparatus (Figure 9-1).

  • The pharyngeal apparatus has four main components:

    • Pharyngeal arches: Five thickened ridges

    • Pharyngeal clefts (grooves): Four indentations between the pharyngeal arches on the external surface of the embryo

    • Pharyngeal pouches: Four recesses between the pharyngeal arches inside the primitive pharynx

    • Pharyngeal membranes: Four thin areas between the pharyngeal arches where the pharyngeal clefts and pouches approach each other

Figure 9-1.

Pharyngeal apparatus. (A) A lateral view of the cranial, cervical, and thoracic portions of a 4-week-old embryo illustrates the pharyngeal arches forming as a series of ridges in the pharyngeal region. Only four pharyngeal arches are shown because the sixth arch has not formed yet. The accompanying photograph shows an embryo of approximately the same age. (B) The internal pharyngeal pouches alternate with the pharyngeal arches and their pharyngeal arch arteries (i.e., the aortic arch arteries). (C) The components of the pharyngeal apparatus are illustrated in a superior view of the floor of the developing pharynx that has been sectioned at the level indicated by the dashed line in panel (B). Note the pharyngeal arches, clefts, pouches, and membranes, as well as the germ layers and contents that comprise each component.

Source: Based on Figure 9.3 in B. K. L. Moore, T. V. N. (Vid) Persaud, and M. G. Torchia, Chapter 9, “Pharyngeal Apparatus, Face, and Neck, in The Developing Human, 11th ed. Elsevier. 2020.

Photographic inset: Courtesy Dr. Bradley R. Smith, University of Michigan, Ann Arbor

Pharyngeal Arches

  • The five pharyngeal arches are numbered 1, 2, 3, 4, and 6 because the fifth arch (which is present in fish and lower vertebrates) either immediately regresses or never forms in humans.

  • Each arch is covered by ectoderm on its external surface and lined by endoderm on its internal surface.

  • Each arch contains the following elements:

    • Mesoderm, which will give rise to muscles

    • Neural crest cells, which will form the skeletal components of the face and the ganglia of the cranial nerves

    • A cranial nerve, which will innervate the muscles derived from each arch and carry sensory information to the brainstem

    • An aortic arch artery (described in Chapter 4)

  • The muscles of the pharyngeal arches do not always attach to ...

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