TY - CHAP M1 - Book, Section TI - Genodermatoses A1 - Sheun Ling Madeline, HO A1 - Hui Yi, CHIA A2 - Sze Hon, CHUA A2 - Suat Hoon, TAN A2 - Chee Leok, GOH A2 - See Ket, NG PY - 2020 T2 - Asian Skin: a Reference Color Atlas of Dermatology and Venereology, Revised 2nd Edition AB - The genetic origin of such dermatoses results in the hereditary nature of the disorder, which means that families and generations may be similarly afflicted. In the last few decades, there has been an explosion of research with the completion of the human genome project in addition to the emergence of array-based methods for linkage analysis and homozygosity mapping. Furthermore, next generation sequencing technology using whole-exome (all transcribed genes) and whole-genome approaches have revolutionized genetic and genomic research. These advances in molecular technology have led to elucidation of the genetic basis of many single-gene inherited skin disorders and have greatly improved our understanding of such conditions. Genotype-phenotype correlations are often complex, with multiple examples of allelic heterogeneity (different mutations in the same gene at the same chromosomal locus causing a single phenotype) and locus heterogeneity (mutations in genes at different chromosomal loci causing the same phenotype). SN - PB - McGraw Hill Education CY - New York, NY Y2 - 2024/10/09 UR - accessworldmed.mhmedical.com/content.aspx?aid=1203993039 ER -