RT Book, Section
A1 Sheun Ling Madeline, HO
A1 Hui Yi, CHIA
A2 Sze Hon, CHUA
A2 Suat Hoon, TAN
A2 Chee Leok, GOH
A2 See Ket, NG
SR Print(0)
ID 1203993039
T1 Genodermatoses
T2 Asian Skin: a Reference Color Atlas of Dermatology and Venereology, Revised 2nd Edition
YR 2020
FD 2020
PB McGraw Hill Education
PP New York, NY
SN 9789814821292
LK accessworldmed.mhmedical.com/content.aspx?aid=1203993039
RD 2024/10/09
AB The  genetic  origin  of  such  dermatoses  results  in  the  hereditary  nature  of  the  disorder,  which  means  that  families  and  generations  may  be  similarly  afflicted.  In  the  last  few  decades,  there  has  been  an  explosion  of  research  with  the  completion  of  the  human  genome  project  in  addition  to  the  emergence  of  array-based  methods  for  linkage  analysis  and  homozygosity  mapping.  Furthermore,  next  generation  sequencing  technology  using  whole-exome  (all  transcribed  genes)  and  whole-genome  approaches  have  revolutionized  genetic  and  genomic  research.  These  advances  in  molecular  technology  have  led  to  elucidation  of  the  genetic  basis  of  many  single-gene  inherited  skin  disorders  and  have  greatly  improved  our  understanding  of  such  conditions.  Genotype-phenotype  correlations  are  often  complex,  with  multiple  examples  of  allelic  heterogeneity  (different  mutations  in  the  same  gene  at  the  same  chromosomal  locus  causing  a  single  phenotype)  and  locus  heterogeneity  (mutations  in  genes  at  different  chromosomal  loci  causing  the  same  phenotype).